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Quality Assurance

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Quality Materials Lead to Quality Results

The Victorian Cancer Biobank (VCB) has a long-standing commitment to quality. Operations are standardized to international best practices, with audit systems in place to ensure compliance and regular testing to assure quality. Dedicated staff control the process, from obtaining consent to collection, storage and data management. This enables VCB to bank consistently high-quality samples and clinical data while protecting patient-donor safety and privacy. Stringent quality control over samples and data is continuously enforced. Moreover, personnel at the collection centres are trained quarterly on technical updates.

ISO Certification

VCB will be obtaining ISO certification in the near future. This means that VCB will meet international standards, not just best practice for high-quality collection, storage and release of human biospecimens.

Standard Operating Procedures

Standard operating procedures (SOPs) have been developed in consultation with pathologists, scientists, consumer groups and ethicists to ensure practical, high quality, standardized sample and data collection and processing across all collection centres and protection of patient-donor safety and privacy. The Victorian Cancer Biobank has developed and implemented protocols covering: ​

  • Tissue sample processing and archiving;
  • Patient data collection and patient identification protection;
  • Equipment maintenance; and
  • Sample distribution to qualified researchers.

These protocols are designed to maximize the molecular and histological integrity and quality of the samples.

Biospecimen Quality

The preservation of materials for research is a careful science. Every step from resection to storage can diminish the usefulness of the specimen for research purposes. The VCB has practices and procedures to ensure excellent quality specimens, including the following collection and storage practices:

  • Tissues are frozen within 60 minutes of collection;
  • Blood is processed and stored within 2 hours of collection.
  • Mirror collections of tissue and blood specimens are stored in -80°C and the vapour phase of liquid nitrogen;
  • All FFPE and O.C.T cases are verified by a pathologist;
  • All FFPE and O.C.T sectioned cases come with a complimentary H&E slide. verification;
  • All samples are labelled with a unique Tissue Bank Number;
  • Storage equipment is checked and monitored daily.

Data Quality

Dedicated specially-trained personnel at each biobank extract comprehensive clinical data from patients and patient’s charts and enter it into a central-database. VCB can provide detailed, non-identifying information to researchers on approximately 400 clinical data elements. Case reviews are conducted quarterly to ensure consistency in data extraction. Data audits are conducted annually to verify compliance and test for data errors.

The database platform used by the VCB is OpenSpecimen™, a Krishagni product.

Training and Compliance

The VCB staff members are qualified medical scientists with formal training in biomedical and/or clinical research, nursing and pathology. Personnel at all of our biobank sites, including the staff at VCB Central Operations are trained and tested on all SOPs annually to ensure compliance and encourage professional development.

Continuous Improvement

VCB is dedicated to continuous improvement and reviews its policies and procedures on an annual basis.